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          可將DSPE-PEG-Cy3脂質(zhì)與通過無銅點(diǎn)擊化學(xué)結(jié)合IV型膠原的肽偶聯(lián)
          
						
          
							發(fā)布時間：2025-06-19     作者：kx   分享到：
							
          
								
          
								
							
          
						
          
						
          
						
          標(biāo)題：Abstract 238: Sub-Endothelial Matrix Targeted Liposomal Nanoparticles For Vascular Therapeutics（用于血管*的亞內(nèi)皮基質(zhì)靶向脂質(zhì)體納米粒子）
          鏈接：https://xueshu.baidu.com/usercenter/paper/show?paperid=a250e60fa47edb2778626375e13802e8&site=xueshu_se
          作者：JS Cudnik，PC West，RK Fisher，Sam Mattern-Schain，M Best，SS Kirkpatrick，MB Freeman，OH Grandas，DJ Mountain
          摘要：
          Objectives: Vascular intervention results in intimal denudation, exposure of the sub-endothelial matrix, and subsequent intimal hyperplasia (IH), under the control of numerous remodeling mechanisms. Reduction of IH-induced restenosis may be achieved by manipulation of these remodeling pathways through targeted molecular inhibition. Spatially-controlled nanoparticles designed to co-localize to exposed sub-endothelial matrices could provide an optimal delivery system for targeted vascular therapeutics. To his end, we aimed to develop the framework for a surface-modified liposomal drug delivery platform designed to preferentially bind collagen type IV. Methods: Non-targeted control liposomes (NTL) were formed with bulk DOPC-PEG, 30% cholesterol, and 0.1 mol% Rhodamine-DOPE. DSPE-PEG-DBCO lipids were conjugated to peptides previously shown to bind collagen IV via copper-free click chemistry and inserted at 5 mol% to form collagen-targeting liposomes (CTL), either at hydration (PreCTL) or by post-insertion via micellar transfer (PostCTL).
          譯文：
          目的：在多種重塑機(jī)制的控制下，血管介入導(dǎo)致內(nèi)膜剝脫、亞內(nèi)皮基質(zhì)暴露和隨后的內(nèi)膜增生（IH）。通過靶向分子抑制操縱這些重塑途徑，可以減少IH誘導(dǎo)的再狹窄。設(shè)計(jì)用于共定位暴露的亞內(nèi)皮基質(zhì)的空間控制納米粒子可以為靶向血管*提供*佳的遞送系統(tǒng)。為此，我們的目標(biāo)是開發(fā)一種表面修飾的脂質(zhì)體藥物遞送平臺的框架，該平臺旨在優(yōu)先結(jié)合IV型膠原蛋白。
          方法：非靶向?qū)φ罩|(zhì)體（NTL）由散裝DOPC-PEG、30%膽固醇和0.1 mol%羅丹明DOPE形成。將DSPE-PEG-DBCO脂質(zhì)與之前顯示的通過無銅點(diǎn)擊化學(xué)結(jié)合IV型膠原的肽偶聯(lián)，并在水合（PreCTL）或通過膠束轉(zhuǎn)移（PostCTL）插入后以5mol%插入形成膠原靶向脂質(zhì)體（CTL）。
          DOI：10.3969/j.issn.1008-987x.2021.03.09
          DSPE-PEG-Cy3
          西安pg電子官方生物提供相關(guān)產(chǎn)品：
          DSPE-PEG-acid
          DSPE-PEG4-acid
          DSPE-PEG-Ald
          DSPE-PEG-Amine，1069-79-0
          DSPE-PEG-azide
          DSPE-PEG5-azide
          DSPE-PEG-Biotin
          DSPE-PEG-Boronate
          DSPE-PEG-CH2COOH
          DSPE-PEG-COOH
          DSPE-PEG-Cy3
          DSPE-PEG-Cy5
          DSPE-PEG-DBCO
          DSPE-PEG-FITC
          DSPE-PEG-Folate
          以上文章內(nèi)容轉(zhuǎn)載自網(wǎng)絡(luò)，如有侵權(quán)請聯(lián)系我們刪除！
          
						
          
						
          
							
							
						
          
					
          
				
          
			
          
		
          
	
          

    







          
		
          
			
			
			
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