文獻(xiàn)：(177)Lu-Labeled Cerasomes Encapsulating Indocyanine Green for Cancer Theranostics

文獻(xiàn)鏈接：https://xueshu.baidu.com/usercenter/paper/show?paperid=c78a5baea5c0fadb51c1d4fff76ee436&site=xueshu_se

作者：L Jing，J Shi，D Fan，Y Li，R Liu，Z Dai，F(xiàn) Wang，J Tian

摘要：This Article reported the fabrication of a robust theranostic cerasome encapsulating indocyanine green (ICG) by incorporating 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)2000]-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid monoamide (DSPE-PEG2000-DOTA), followed by chelating radioisotope of 177Lu. Its applications in optical and nuclear imaging of tumor uptake and biodistribution, as well as photothermal killing of cancer cells, were investigated. It was found that the obtained cerasome could act efficiently as fluorescence contrast agent as well as nuclear imaging tracer. Encapsulating ICG into cerasome could protect ICG from degradation, aggregation, and fast elimination from body, resulting in remarkable improvement in near-infrared fluorescence imaging, photothermal stability, and in vivo pharmacokinetic profile.

本文報(bào)道了通過(guò)摻入1,2-二硬脂�；�-sn-甘油-3-磷乙醇胺-N-[羧基（聚乙二醇）2000]-1,4,7,10-四氮雜環(huán)十二烷-1,4,7,10-四乙酸單酰胺（DSPE-PEG2000-DOTA），然后加入177Lu的螯合放射性同位素，制備了一種包封吲哚菁綠（ICG）的堅(jiān)固的治療性陶瓷體。

研究了其在腫瘤攝取和生物分布的光學(xué)和核成像以及細(xì)胞的光熱殺傷中的應(yīng)用。研究發(fā)現(xiàn)，所獲得的陶瓷體可以作為熒光造影劑和核成像示蹤劑。

將ICG封裝在陶瓷體內(nèi)可以保護(hù)ICG免受降解、聚集和快速?gòu)捏w內(nèi)消除，從而顯著改善近紅外熒光成像、光熱穩(wěn)定性和體內(nèi)藥代動(dòng)力學(xué)特性。

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