DSPE-PEG-FA修飾納米顆粒用于增強(qiáng)*細(xì)胞攝取與核定位釋放

鏈接：https://pubs.acs.org/doi/abs/10.1021/acsami.5b05038

作者：楊麗，林金艷，楊祥瑞，李彥修，吳世超，玉皇，葉社芳，謝麗婭，戴理宗，侯真慶

摘要：

結(jié)合絲裂霉素C (MMC)–磷脂復(fù)合物可提高藥物包封率并減少藥物過早釋放以及DSPE-PEG-葉酸 (DSPE-PEG-FA) 可用于特異性靶向*的優(yōu)勢，我們報(bào)道了一種簡單的一鍋?zhàn)越M裝路線來制備載有MMC–磷脂復(fù)合物的DSPE-PEG基納米顆粒 (MP-PEG-FA NPs)。共聚焦成像和流式細(xì)胞術(shù)均表明，在細(xì)胞攝取和細(xì)胞內(nèi)藥物遞送后，MMC分布到細(xì)胞核中。更重要的是，全身給藥的MP-PEG-FA NPs可增加HeLa*裸鼠的血液持久性和增強(qiáng)的*蓄積。本研究介紹了一種簡單有效的策略來設(shè)計(jì)基于*癌藥物–磷脂復(fù)合物的靶向藥物遞送系統(tǒng)，以實(shí)現(xiàn)持續(xù)/控制的藥物釋放。

譯文：

Integrating advantages of mitomycin C (MMC)–phospholipid complex for increased drug encapsulation efficiency and reduced premature drug release, DSPE-PEG-folate (DSPE-PEG-FA) for specific tumor targeting, we reported a simple one-pot self-assembly route to prepare the MMC–phospholipid complex-loaded DSPE-PEG-based nanoparticles (MP-PEG-FA NPs). Both confocal imaging and flow cytometry demonstrated that MMC was distributed into nuclei after cellular uptake and intracellular drug delivery. More importantly, the systemically administered MP-PEG-FA NPs led to increased blood persistence and enhanced tumor accumulation in HeLa tumor-bearing nude mice. This study introduces a simple and effective strategy to design the anticancer drug–phospholipid complex-based targeted drug delivery system for sustained/controlled drug release.

西安pg電子官方生物提供相關(guān)產(chǎn)品：

DSPE-PEG-Boronate

DSPE-PEG-CH2COOH

DSPE-PEG-COOH

DSPE-PEG-Cy3

DSPE-PEG-Cy5

DSPE-PEG-DBCO

DSPE-PEG-FITC

DSPE-PEG-Folate

DSPE-PEG-IA

DSPE-PEG-Mal

DSPE-PEG-NH2

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