文獻(xiàn)：

Targeting Fluorescence Imaging of RGD-Modified Indocyanine Green Micelles on Gastric Cancer

文獻(xiàn)鏈接：

https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2020.575365/full

作者：

Jun Shao&#x;Jun Shao1?Xiaoming Zheng&#x;Xiaoming Zheng1?Longbao FengLongbao Feng2Tianyun LanTianyun Lan3Dongbing DingDongbing Ding1Zikai CaiZikai Cai1Xudong ZhuXudong Zhu1Rongpu LiangRongpu Liang1Bo Wei*Bo Wei1*

As shown in Scheme 1, first, DSPE-PEG-RGD was obtained based on the Michael addition reaction between RGD peptide and DSPE-PEG-Mal. Second, the NIR agent ICG was encapsulated by the DSPE-PEG-RGD matrix via the self-assembly method. DSPE-PEG-Mal is an amphiphilic polymer. PEG serves as a hydrophilic unit to form the shell while DSPE is a hydrophobic unit to form the hydrophobic cavity with ICG in the core. The synthesis and Characteristics of DSPE-PEG-RGD@ICG were analyzed, including 1H NMR spectroscopy, transmission electron microscope (TEM), and so on. Then, the cellular uptake and biocompatibility were assessed. In addition, by using an optical imaging system, we observed the biodistribution and improved accumulation of DSPE-PEG-RGD@ICG in the tumor. The results of this study may provide a promising nanocarrier to realize the future clinical application of optical molecular imaging in early diagnosis and accurate resection of GC.

首先，基于RGD肽和DSPE-PEG-Mal之間的Michael加成反應(yīng)獲得DSPE-PEG-RGD。其次，通過(guò)自組裝方法將近紅外試劑ICG包封在DSPE-PEG-R GD基質(zhì)中。

DSPE-PEG-Mal是一種兩親性聚合物。PEG作為親水單元形成外殼，而DSPE作為疏水單元形成疏水腔，ICG位于核心。合成及其特性DSPE-PEG-RGD@ICG通過(guò)1H NMR光譜、透射電子顯微鏡（TEM）等進(jìn)行分析，然后評(píng)估細(xì)胞攝取和生物相容性。

此外，通過(guò)使用光學(xué)成像系統(tǒng)，我們觀察了DSPE-PEG-RGD@ICG在腫瘤中。本研究的結(jié)果可能為實(shí)現(xiàn)光學(xué)分子成像在GC早期診斷和準(zhǔn)確切除中的未來(lái)臨床應(yīng)用提供有前景的納米載體。

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