文獻(xiàn)：Preparation, characterization, in vitro, and in vivo assessment of bortezomib-loaded poly (ethylene glycol)-distearyl phosphatidylethanolamine nanomicelles

作者：Hou, Jian PhD; Zong, Zhengtao BS; Zhu, Feng MS; Ge, Yuhong BS; Li, Chunyan MS; Hu, Canhui MS; Chen, Zaixin PhD*

文獻(xiàn)鏈接：https://journals.lww.com/ijsoncology/fulltext/9900/preparation,_characterization,_in_vitro,_and_in.23.aspx

Poly (ethylene glycol)-distearyl phosphatidylethanolamine (mPEG-DSPE) is an amphiphilic block copolymer comprising hydrophilic head and hydrophobic tail. Due to its safety and biocompatibility, it has been approved by the U.S. FDA and extensively used as pharmaceutical excipient in polymeric micellar systems. This application has been extensively reviewed by Wang et al[22], highlighting its biocompatibility, targeting capabilities, and sustained drug release properties. Gill further elucidated the structure-function relationships of PEG-lipid micelles, providing a systematic analysis of their physicochemical determinants, formulation optimization strategies, and biological interactions in targeted delivery systems[23]. In this study, mPEG-DSPE was utilized to formulate BTZ polymer micelles (BTZ/PM), aiming to boost the antitumor activity of the drug during delivery while reducing its toxicity and side effects. 

聚乙二醇-二硬脂基磷脂酰乙醇胺（mPEG-DSPE）是一種兩親性嵌段共聚物，包括親水性頭部和疏水性尾部。

進(jìn)行了廣泛的綜述，強(qiáng)調(diào)了其生物相容性、靶向能力和持續(xù)藥物釋放特性。Gill進(jìn)一步闡明了PEG脂質(zhì)膠束的結(jié)構(gòu)-功能關(guān)系，對其物理化學(xué)決定因素、制劑優(yōu)化策略和靶向遞送系統(tǒng)中的生物相互作用進(jìn)行了系統(tǒng)分析。在這項(xiàng)研究中，mPEG-DSPE被用來配制BTZ聚合物膠束（BTZ/PM），旨在提高藥物在遞送過程中的抗腫瘤活性，同時(shí)降低其毒性和副作用。

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