文獻(xiàn)：Targeted folic acid-PEG nanoparticles for noninvasive imaging of folate receptor by MRI

作者：Ting-Jung Chen, Tsan-Hwang Cheng, Yu-Chin Hung, Kuei-Tang Lin, Gin-Chung Liu, Yun-Ming Wang

文獻(xiàn)鏈接：https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.a.31752

摘要：

The surface of superparamagnetic iron oxide nanoparticles (SPIO) with different molecular weight of poly(ethylene glycol) (PEG) and folic acid (FA) were synthesized. The SPIO-PEG-FA nanoparticles are well-dispersed and have good stability in various pH solutions. The lack of hysterestis and remanence at ambient temperatures is characteristic of superparamagnetic materials for SPIO-PEG-FA. The uptake by macrophage for SPIO-PEG-FA is lower than that of Feridex I.V. even at higher concentration. Internalization of SPIO-PEG-FA in targeted cells (KB cells) was observed by flow-cytometric analysis and in vitro MR imaging. The intensity change of positive KB cell tumor (?20 to 25%) is significantly lower than that of negative HT-1080 cell tumor from precontrast to postcontrast images of the tumor by in vivo MR imaging. These preliminary results demonstrated that SPIO-PEG-FA have the ability to target folate receptor.  

合成了不同分子量聚乙二醇（PEG）和葉酸（FA）的超順磁性氧化鐵納米粒子（SPIO）表面。SPIO-PEG-FA納米粒子分散良好，在各種pH溶液中具有良好的穩(wěn)定性。

在環(huán)境溫度下缺乏磁滯和剩磁是SPIO-PEG-FA的超順磁性材料的特征。即使在更高的濃度下，巨噬細(xì)胞對SPIO-PEG-Fe的攝取也低于Feridex I.V。通過流式細(xì)胞術(shù)分析和體外MR成像觀察SPIO-PEG-FA在靶細(xì)胞（KB細(xì)胞）中的內(nèi)化。

通過體內(nèi)MR成像，從腫瘤的造影前圖像到造影后圖像，陽性KB細(xì)胞腫瘤的強(qiáng)度變化（-20%至25%）明顯低于陰性HT-1080細(xì)胞腫瘤。這些初步結(jié)果表明，SPIO-PEG-FA具有靶向葉酸受體的能力。

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