產(chǎn)品名稱(chēng)：

3-AP，143621-35-6

產(chǎn)地：西安

規(guī)格：1mg 5mg 10mg

純度：99%

用途：僅用于科研

溫馨提示：僅用于科研，不能用于人體實(shí)驗(yàn)！

Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is an excellent target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation.1 3-AP is a ribonucleotide reductase inhibitor and iron chelator with antitumor activity.2 At 5 μM it can enhance DU145, U251, and PSN1 tumor cell radiosensitivity in vitro, inhibiting DNA synthesis and repair.2 It destroys the tyrosine free radical in the R2/p53R2 subunits of ribonucleotide reductase by forming a redox active complex with iron, thus producing reactive oxygen species.3 Furthermore, 3-AP has been shown to activate an endoplasmic reticulum stress pathway, leading to the unfolded protein response and apoptosis.4

相關(guān)產(chǎn)品：

Alantolactone，546-43-0

Procyanidin C1，37064-30-5

Reuterin，2134-29-4，3-hydroxy-propanal

編輯：XAQYBIO HAO，2023年3月15日。