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        • ǰλã > ϿƌW > > ˎf > ֬ > DOPE-Biotin ֬Ҵ
          DOPE-Biotin ֬Ҵ

          l(f)rg2022-04-02 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-BiotinDOPEIJػԻF

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          Q-0009755 500mg
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          Q-0009755 1g
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          17778955912
          1521565887
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          DOPE-Biotin

          ֬Ҵ

          1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-Biotin

          DOPEIJػԻF

          1,2--SN--3-Ҵ;cϳɷ

          1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine(DOPE)x֬|(zh)wo֬|(zh)(helperlipid)cx֬Y(ji)siRNAD(zhun)ȾЧ
          cIC50:helperlipidforliposome

          Inthisstudy,eachsiRNAisencapsulatedinLNP(cationiclipid-A:PEG2000-DMPE:DOPE=47.8:5.18:47.1molarpercent).WiththeneutrallipidfortheLNPisDOPE,LNPexertsknock-down(KD)effectonmacrophagesandDCsandLiposome-containingDOPEshowsfusogenicity.LNP/siRNAsignificantlysuppressesCD45proteinexpressionataninhibitionrateof30%onmacrophagesandDCsbutnotonmonocytes,neutrophils,plasmacytoidDCs,orBcells.LNPhasthepotentialtobeanefficientsiRNAdeliverysystemnotonlyformurinebutalsoforhumanmacrophagesandDCs.

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          DSPE-PEG2k-Mannose¶DSPE-PEG2000pegķ10002000,3400,5000 ҂ṩ@a(chn)Ʒ HҪgӭԃ

          pgӹٷƼ޹˾ṩ 4ME 16:0 PC ^N/A N/A Hʹã

          l(f)rg2022-04-02 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-ThiolDOPEIJɎԻF

          l(f)rg2022-04-02 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-Succinic acidDOPEIJȻԻF