l(f)rg2022-04-02 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-BiotinDOPEIJػԻF
؛̖ | Ҏ(gu) | (sh) | r |
---|---|---|---|
Q-0009755 | 100mg |
1
|
ԃr |
Q-0009755 | 250mg |
1
|
ԃr |
Q-0009755 | 500mg |
1
|
ԃr |
Q-0009755 | 1g |
1
|
ԃr |
Q-0009755 | 5g |
1
|
ԃr |

DOPE-Biotin
֬Ҵ
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-Biotin
DOPEIJػԻF
1,2--SN--3-Ҵ;cϳɷ
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine(DOPE)x֬|(zh)wo֬|(zh)(helperlipid)cx֬Y(ji)siRNAD(zhun)ȾЧ
cIC50:helperlipidforliposome
wо
Inthisstudy,eachsiRNAisencapsulatedinLNP(cationiclipid-A:PEG2000-DMPE:DOPE=47.8:5.18:47.1molarpercent).WiththeneutrallipidfortheLNPisDOPE,LNPexertsknock-down(KD)effectonmacrophagesandDCsandLiposome-containingDOPEshowsfusogenicity.LNP/siRNAsignificantlysuppressesCD45proteinexpressionataninhibitionrateof30%onmacrophagesandDCsbutnotonmonocytes,neutrophils,plasmacytoidDCs,orBcells.LNPhasthepotentialtobeanefficientsiRNAdeliverysystemnotonlyformurinebutalsoforhumanmacrophagesandDCs.
ȣ98%
bƿb
Ҏ(gu)mgcge
fSAͨͨ
a(chn)أ
(yng)̣pgӹٷƼ˾

(sh)Ϣ | |
---|---|
^B(ti) | wĩ |
|(zh)ָˣ | 95%+ |
ܽl | ЙC܄/ˮ |
CAS̖ | N/A |
N/A | |
l | -20ܹⱣ |
rg | 1 |
\ݔl | Ҝ2 |
a(chn)Sң | pgӹٷƼ˾ |
-
DSPE-PEG2k-Mannose¶DSPE-PEG2000pegķ10002000,3400,5000 ҂ṩ@a(chn)Ʒ HҪgӭԃ
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pgӹٷƼ˾ṩ 4ME 16:0 PC ^N/A N/A Hʹã
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l(f)rg2022-04-02 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-ThiolDOPEIJɎԻF
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l(f)rg2022-04-02 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-Succinic acidDOPEIJȻԻF