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葫蘆[10]脲主體超分子的制備方法
葫蘆[10]脲主體超分子的制備方法
葫蘆[n]脲（Cucurbit[n]uril，n = 5~8，10，13~15）, 是繼冠醚、環(huán)糊精、杯芳烴之后備受矚目的新一代主體分子，在分子識(shí)別、載藥與釋放、熒光成像、金屬配位化學(xué)、超分子催化、超分子納米反應(yīng)器以及自組裝超分子材料等領(lǐng)域中均展現(xiàn)出廣闊的應(yīng)用前景。葫蘆[10]脲是葫蘆[n]脲家族中擁有較大空腔體積（~ 870 ?3）的成員，已展現(xiàn)出有別于其他葫蘆[n]脲的特異識(shí)別性能，如空腔能容納較大尺寸分子如葫蘆[5]脲、杯[4]芳烴、金屬卟啉、環(huán)蕃Blue Box和穴醚等。然而，葫蘆[10]脲的研究進(jìn)展遠(yuǎn)遠(yuǎn)滯后于同期被發(fā)現(xiàn)的其他葫蘆[n]脲同系物，原因在于葫蘆[10]脲的分離純化相當(dāng)困難。
較近，武漢科技大學(xué)**材料與納米技術(shù)研究院劉思敏教授課題組利用葫蘆[10]脲與某些客體分子形成的包合物易于沉淀的性質(zhì)，發(fā)展了一種簡便、**的分離純化葫蘆[10]脲的新方法（圖1）。
圖1 葫蘆[10]脲分離純化示意圖。
研究發(fā)現(xiàn)，在諸多商業(yè)可得的胺類化合物中，正辛胺鹽酸鹽、金剛烷胺鹽酸鹽和3,5-二甲基金剛烷胺鹽酸鹽作為特殊客體均能**的從葫蘆[10]脲?葫蘆[5]脲粗產(chǎn)物中選擇性置換掉葫蘆[5]脲并與葫蘆[10]脲形成包合物沉淀。通過簡單的溶劑洗滌即可除去包合物中的客體分子。核磁氫譜以及電噴霧質(zhì)譜（ESI-MS）結(jié)果顯示，葫蘆[10]脲與這三個(gè)客體分子均可形成化學(xué)計(jì)量比為1:2的三元包合物。該純化方法的建立為推動(dòng)葫蘆[10]脲化學(xué)的快速發(fā)展提供了新的機(jī)遇。
超分子材料供應(yīng)：
| 中文名稱 | 英文名稱 | cas號(hào) |
| 1,3,5-均苯三甲酸 | 1,3,5-Benzenetricarboxylicacid | 554-95-0 |
| 三(4-甲酰苯基)胺 | Tris(4-formylphenyl)amine | 119001-43-3 |
| 硬脂酸-聚乙二醇-琥珀酰亞胺酯 | SA-PEG-NHS,averageM.W.2000 | |
| 1,3,5-苯三甲醇 | 1,3,5-Benzenetrimethanol | 4464-18-0 |
| 3,5-二叔丁基苯甲酸 | 3,5-Di-tert-butylbenzoicacid | 16225-26-6 |
| 3,5-二叔丁基苯胺 | 3,5-Di-tert-butylaniline | 2380-36-1 |
| 3,5-雙(叔丁基)苯甲醛 | 3,5-Di-tert-butyl-benzaldehyde, | 17610-00-3 |
| 3,5-二甲氧基芐醇 | 3,5-Dimethoxybenzylalcohol | 705-76-0 |
| 硬脂酸-聚乙二醇-羧基 | SA-PEG-COOH | |
| 二苯基乙醛 | Diphenylacetaldehyde | 947-91-1 |
| 3,5-二叔丁基芐醇 | 3,5-Di-tert-butylbenzylAlcohol | 77387-57-6 |
| 3,5-二叔丁基芐溴 | 3,5-Di-tert-butylbenzylBromide | 62938-08-3 |
| 二苯基乙酰氯 | DiphenylacetylChloride | 1871-76-7 |
| 3,5-二叔丁基苯酚 | 3,5-Di-tert-butylphenol | 1138-52-9 |
| 2,2-Diphenylethanol | 1883-32-5 | |
| 9-(bromomethyl)-9H-fluorene | 56954-81-5 | |
| 4,4'-偶氮吡啶 | 4,4'-Azopyridine | 2632-99-7 |
| 4,4-二氨基聯(lián)苯（標(biāo)樣） | 4,4'-Benzidine10μg/mLinAcetonitrile | 92-87-5 |
| 偶氮苯-4,4-二羧酸 | Azobenzene-4,4'-dicarboxylicAcid | 586-91-4 |
| 4,4’-雙(氯甲基)-1,1’-聯(lián)苯 | 4,4'-Bis(chloromethyl)-1,1'-biphenyl | 1667-10-3 |
| α,α'-二溴對(duì)二甲苯 | α,α'-Dibromo-p-xylene | 623-24-5 |
| 9,10-二（溴甲基）蒽 | 9,10-BIS(BROMOMETHYL)ANTHRACENE | 34373-96-1 |
| 6-(Aminomethyl)-2-naphthol | 199387-77-4 | |
| 4,4'-Bis(bromomethyl)-2,2'-bipyridine | 134457-14-0 | |
| 2-吡啶甲醛 | 2-Pyridinecarboxaldehyde | 1121-60-4 |
| 4,4'-聯(lián)苯四甲酸二酐 | 4,4'-Biphthalicanhydride | 2420-87-3 |
| 3,4,9,10-苝四甲酸二酐 | 3,4,9,10-Perylenetetracarboxylicdianhydride | 128-69-8 |
| 均苯四甲酸二酐 | Pyromelliticdianhydride | 89-32-7 |
| 4-氨基-1,8-萘二胺 | 4-Amino-1,8-naphthalimide | 1742-95-6 |
| 萘-1,4,5,8-四羧酸二酐 | Naphthalene-1,4,5,8-tetracarboxylicDianhydride | 81-30-1 |
| 1,8:4,5-萘四甲�；䜩啺� | 1,8:4,5-Naphthalenetetracarboxdiimide | 5690-24-4 |
| 均苯四甲酰二亞胺 | PyromelliticDiimide | 2550-73-4 |
| 硬脂酸-聚乙二醇-羅丹明平均分子量3400 | SA-PEG-Rhodamine | |
| 硬脂酸-聚乙二醇-羅丹明平均分子量5000 | ||
| 硬脂酸-聚乙二醇-羅丹明平均分子量2000 | ||
| 硬脂酸-聚乙二醇-羅丹明平均分子量3500 | ||
| 硬脂酸-聚乙二醇-生物素,平均分子量5000 | ||
| 1,1'-二芐基-4,4'-聯(lián)吡啶鎓鹽二氯化物 | 1,1'-Dibenzyl-4,4'-bipyridiniumDichloride | 1102-19-8 |
| 2,2'-聯(lián)吡啶-3,3'-二羧酸 | [2,2'-Bipyridine]-3,3'-dicarboxylicacid | 4433/1/6 |
| 1,1′-二甲基-4,4′-二吡啶二氯化物 | 1,1'-Dimethyl-4,4'-bipyridiniumDichloride | 1910-42-5 |
| 二氯百草枯 | ParaquatDichloride | 1910-42-5 |
| 六溴-O6-冠[3]芳烴[3]四嗪 | Hexabromo-O6-corona[3]arene[3]tetrazine | 1642594-07-7 |
| 六酯基-O6-冠[3]芳烴[3]四嗪 | Hexester-O6-corona[3]arene[3]tetrazine | 1642594-08-8 |
| 硬脂酸-聚乙二醇-馬來酰亞 | SA-PEG-Mal | |
| 硬脂酸-聚乙二醇-葉酸,平均分子量3400 | SA-PEG-FA,averageM.W.3400 | |
| 葫蘆[5]脲 | Cucurbit[5]uril(CB[5])ammoniumsulfatehydrate, | 259886-49-2 |
| 葫蘆[6]脲(CB[6])水合物 | Cucurbit[6]uril(CB[6])hydrate | 80262-44-8 |
| 葫蘆[7]脲 | Cucurbit[7]uril(CB[7])hydrate | 259886-50-5 |
| 葫蘆[8]脲 | Cucurbit[8]uril(CB[8])hydrate | 259886-51-6 |
| [12]環(huán)對(duì)苯撐 | [12]Cycloparaphenylene | 1092522-75-2 |
| [5]環(huán)對(duì)苯撐 | [5]Cycloparaphenylene | 96100-94-6 |
| [6]環(huán)對(duì)苯撐 | [6]Cycloparaphenylene | 156980-13-1 |
| [9]環(huán)對(duì)苯撐 | [9]Cycloparaphenylene | 1092522-74-1 |
| [10]環(huán)對(duì)苯撐 | [10]Cycloparaphenylene | 1222105-46-5 |
| [11]環(huán)對(duì)苯撐 | [11]Cycloparaphenylene | 1222105-48-7 |
| [8]環(huán)對(duì)苯撐 | [8]Cycloparaphenylene | 1217269-85-6 |
| [7]環(huán)對(duì)苯撐 | [7]Cycloparaphenylene | 1222105-42-1 |
| 派瑞林-N | Parylene N | 1633-22-3 |
| 硬脂酸-聚乙二醇-熒光素, 平均分子量 2000 | SA-PEG-FITC, average M.W. 2000 | |
| 環(huán)雙(百草枯-1,4-亞苯基)四(六氟磷酸鹽) | Cyclobis(paraquat-1,4-phenylene) Tetrakis(hexafluorophosphate) | 117271-77-9 |
| 1,11-二氧[11]對(duì)環(huán)芳烷 | 1,11-Dioxa[11]paracyclophane | 6571-51-3 |
| 4,5,7,8,12,13,15,16-八氟[2.2]對(duì)環(huán)芳烷 | 4,5,7,8,12,13,15,16-Octafluoro[2.2]paracyclophane | 1785-64-4 |
| [2.2]二聚對(duì)二甲苯 | [2.2]Paracyclophane | 1633-22-3 |
| 1,6,20,25-四氮雜[6.1.6.1]對(duì)環(huán)芳烷 | 1,6,20,25-Tetraaza[6.1.6.1]paracyclophane | 74043-83-7 |
| 三蝶烯衍生物大三環(huán)二苯并-[18]-冠-6主體分子 | Triptycene-derived macrotricyclic host containing two dibenzo-[18]-crown-6 moieties | 1358730-81-0 |
| 三蝶烯衍生物大三環(huán)二苯并-[24]-冠-8主體分子 | Triptycene-derived macrotricyclic host containing two dibenzo-[24]-crown-8 moieties | 876460-53-6 |
| 三蝶烯衍生物大三環(huán)二苯并-[30]-冠-10主體分子 | Triptycene-derived macrotricyclic host containing two dibenzo-[30]-crown-10 moieties | 1236353-98-2 |
| 三蝶烯衍生物大三環(huán)蒽類主體分子 | Triptycene-derived macrotricyclic host containing an anthracene unit | 951166-02-2 |
| 三蝶烯衍生物雙冠醚主體分子 | Triptycene-derived bis(crown ether) host | 883229-16-1 |
| 三蝶烯衍生物鉗形分子 | Triptycene-derived molecular tweezer | 928880-36-8 |
| 三蝶烯衍生物二對(duì)苯撐-34-冠-10 | Triptycene-derived bisparaphenylene-34-crown-10 | 1211739-99-9 |
| 五蝶烯衍生物單冠醚 | Pentiptycene-derived mono(crown ether)s | 1188318-00-4 |
| 五蝶烯衍生物 cis-雙冠醚 | Pentiptycene-derived cis-bis(crown ether)s | 1146115-33-4 |
| 三蝶烯衍生物三冠醚 | Triptycene-derived tri(crown ether)s | 865539-67-9 |
| 二氯-氧雜杯[2]芳烴[2]三嗪 | Dichloro-oxacalix[2]arene[2]triazine | 819065-56-0 |
| 二氯-氮雜杯[2]芳烴[2]三嗪 | Dichloro-diazadioxacalix[2]arene[2]triazine, | 51421-67-1 |
| 四氮雜杯[4]吡啶 | Tetraazacalix[4]pyridine | 502763-15-7 |
| 苯基高氯酸銅 | Phenylcopper(III) perchlorate | 1169706-62-0 |
| 4-叔丁基硫雜杯[4]芳烴 | 4-tert-Butylthiacalix[4]arene | 182496-55-5 |
| 4-叔丁基-1-(乙氧羰基甲氧基)硫雜杯[4]芳烴 | 4-tert-Butyl-1-(ethoxycarbonylmethoxy)thiacalix[4]arene | 210706-03-9 |
| 4-叔丁基磺酰杯[4]芳烴 | 4-tert-Butylsulfonylcalix[4]arene | 204190-49-8 |
| 4-磺酸基硫雜[4]芳烴鈉鹽 | 4-Sulfothiacalix[4]arene Sodium Salt | 211561-04-5 |
| 4-叔丁基杯[4]芳烴 | 4-tert-Butylcalix[4]arene | 60705-62-6 |
| 4-叔丁基杯[6]芳烴 | 4-tert-Butylcalix[6]arene | 78092-53-2 |
| 杯[4]芳烴 | Calix[4]arene | 74568-07-3 |
| 硬脂酸-聚乙二醇-熒光素, 平均分子量 3400 | SA-PEG-FITC, average M.W. 3400 | |
| 4-叔丁基杯[8]芳烴 | 4-tert-Butylcalix[8]arene | 68971-82-4 |
| 4-叔丁基杯[5]芳烴 | 4-tert-Butylcalix[5]arene | 81475-22-1 |
| 杯[8]芳烴 | Calix[8]arene | 82452-93-5 |
| 杯[6]芳烴 | Calix[6]arene | 96107-95-8 |
| 4-磺酰杯[4]芳烴 水合物 | 4-Sulfocalix[4]arene Hydrate | 112269-92-8 |
| 4-磺酰杯[6]芳烴 水合物 | 4-Sulfocalix[6]arene Hydrate | 102088-39-1 |
| 4-磺酸杯[8]芳烴 水合物 | 4-Sulfocalix[8]arene Hydrate | 137407-62-6 |
| C-甲基杯[4]烴間苯二酚 | C-Methylcalix[4]resorcinarene | 65338-98-9 |
| C-十一烷基杯[4]烴間苯二酚一水合物 | C-Undecylcalix[4]resorcinarene monohydrate | 112247-07-1 |
| 4-磺酸基-杯[6]芳烴水合物 | 4-Sulfonic-calix[6]arene hydrate | 205652-55-7 |
| 1-氮雜-15-冠醚-5 | 1-Aza-15-crown-5 | 66943-05-3 |
| 二苯并-18-冠醚-6 | Dibenzo-18-crown-6 | 14187-32-7 |
| 三蝶烯衍生物雙大三環(huán)主體分子 | Triptycene-derived bis-macrotricyclic host | 1255128-88-1 |
| 手性三蝶烯衍生物三冠醚 | Chiral triptycene-derived tri(crown ether)s | 910794-39-7 |
| 15-冠醚-5 | 15-Crown-5 | 33100-27-5 |
| 苯并-18-冠-6-醚 | Benzo-18-crown-6 | 14098-24-9 |
| 1,4,8,11-四氮雜環(huán)十四烷 | 1,4,8,11-Tetraazacyclotetradecane | 295-37-4 |
| 1,4,7,10-四氮雜環(huán)十二烷, 水分:≤2.0% | 1,4,7,10-Tetraazacyclododecane, 98%, water:≤2.0% | 294-90-6 |
| 硬脂酸-聚乙二醇-熒光素, 平均分子量 5000 | SA-PEG-FITC, average M.W.5000 | |
| 苯并-15-冠-5 | Benzo-15-crown-5 | 14098-44-3 |
| 4,4-二苯并-24-冠醚-8 | Dibenzo-24-crown 8-Ether | 14174-09-5 |
| 4'-氨基苯并-15-冠5-醚 | 4'-Aminobenzo-15-crown 5-ether | 60835-71-4 |
| 4,7,13,16,21,24-六氧雜-1,10-二氮雜雙環(huán)[8.8.8]二十六烷 | 4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane | 23978-09-8 |
| 18-冠醚-6 | 18-Crown-6 | 17455-13-9 |
| 1-氮雜-18-冠-6-醚 | 1-Aza-18-crown 6-Ether | 33941-15-0 |
| 1-氮雜-12-冠4-醚 | 1-Aza-12-crown 4-Ether | 41775-76-2 |
| 4'-乙酰苯并-15-冠-5-醚 | 4'-Acetylbenzo-15-crown 5-Ether | 41757-95-3 |
| 4'-乙酰苯并-18-冠-6-醚 | 4'-Acetylbenzo-18-crown 6-Ether | 41855-35-0 |
| 苯并-12-冠4-醚 | Benzo-12-crown 4-Ether | 14174-08-4 |
| 4'-溴苯并-18-冠6-醚 | 4'-Bromobenzo-18-crown 6-Ether | 75460-28-5 |
| 4'-溴苯并-15-冠5-醚 | 4'-Bromobenzo-15-crown 5-Ether | 60835-72-5 |
| 雙(1,4-亞苯基)-34-冠10-醚 | Bis(1,4-phenylene)-34-crown 10-Ether | 53914-95-7 |
| 4'-羧基苯并-15-冠5-醚 | 4'-Carboxybenzo-15-crown 5-Ether | 56683-55-7 |
| 4'-羧基苯并-18-冠6-醚 | 4'-Carboxybenzo-18-crown 6-Ether | 60835-75-8 |
| N,N'-二芐基-4,13-二氮雜-18-冠6-醚 | N,N'-Dibenzyl-4,13-diaza-18-crown 6-Ether | 69703-25-9 |
| 4,13-二氮雜-18-冠-6-醚 | 4,13-Diaza-18-crown 6-Ether | 23978-55-4 |
| 4,10-二氮雜-12-冠4-醚 | 4,10-Diaza-12-crown 4-Ether | 294-92-8 |
| 4,10-二氮雜-15-冠5-醚 | 4,10-Diaza-15-crown 5-Ether | 31249-95-3 |
| 二苯并-15-冠5-醚 | Dibenzo-15-crown 5-Ether | 14262-60-3 |
| 二苯并-21-冠7-醚 | Dibenzo-21-crown 7-Ether | 14098-41-0 |
| 4'-甲酰苯并-15-冠-5-醚 | 4'-Formylbenzo-15-crown 5-Ether | 60835-73-6 |
| 4'-甲酰苯并-18-冠-6-醚 | 4'-Formylbenzo-18-crown 6-Ether | 60835-74-7 |
| 2-(羥甲基)-12-冠4-醚 | 2-(Hydroxymethyl)-12-crown 4-Ether | 75507-26-5 |
| 2-(羥甲基)-15-冠5-醚 | 2-(Hydroxymethyl)-15-crown 5-Ether | 75507-25-4 |
| 2-(羥甲基)-18-冠6-醚 | 2-(Hydroxymethyl)-18-crown 6-Ether | 70069-04-4 |
| 4'-硝基苯并-15-冠-5-醚 | 4'-Nitrobenzo-15-crown 5-Ether | 60835-69-0 |
| 4'-硝基苯并-18-冠-6-醚 | 4'-Nitrobenzo-18-crown 6-Ether | 53408-96-1 |
| N-苯氮雜-15-冠-5-醚 | N-Phenylaza-15-crown 5-Ether | 66750-10-5 |
| 2,3-萘并-15-冠醚-5 | 2,3-Naphtho-15-crown-5 | 17454-47-6 |
| 二苯并-30-冠-10 | Dibenzo-30-crown-10 | 17455-25-3 |
| 2-Aminomethyl-15-crown-5 | 83585-56-2 | |
| 2-氨基甲基-18-冠-6 | 2-Aminomethyl-18-crown-6 | 83585-61-9 |
| 4′-Amino-5′-nitrobenzo-15-crown-5 | 77001-50-4 | |
| 1,4,8,11-四(乙氧碳酰甲基)-1,4,8,11-四氮環(huán)十四烷 | 1,4,8,11-Tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid, tetraethyl ester | 126320-57-8 |
| 1,4,8,12-四氮雜環(huán)十五烷 | 1,4,8,12-Tetraazacyclopentadecane | 15439-16-4 |
| 4'-氨基苯并-18-冠醚-6 | 2,3,5,6,8,9,11,12,14,15-Decahydro-1,4,7,10,13,16-benzohexaoxacyclooctadecin-18-amine | 68941-06-0 |
| α-環(huán)糊精 | α-Cyclodextrin | 10016-20-3 |
| γ-環(huán)糊精 | γ-Cyclodextrin | 17465-86-0 |
| β-環(huán)糊精 | β-Cyclodextrin | 7585-39-9 |
| 3A-氨基-3A-脫氧-(2AS,3AS)-β-環(huán)糊精 水合物 | 3A-Amino-3A-deoxy-(2AS,3AS)-beta-cyclodextrin Hydrate | 117194-77-1 |
| 3A-氨基-3A-脫氧-(2AS,3AS)-α-環(huán)糊精 | 3A-Amino-3A-deoxy-(2AS,3AS)-alpha-cyclodextrin | 121916-94-7 |
| 3A-氨基-3A-脫氧-(2AS,3AS)-γ-環(huán)糊精 水合物 | 3A-Amino-3A-deoxy-(2AS,3AS)-gamma-cyclodextrin Hydrate | 189307-64-0 |
| 單-6-O-(對(duì)甲苯磺�；�)-β-環(huán)糊精 | Mono-6-O-(p-toluenesulfonyl)-beta-cyclodextrin | 67217-55-4 |
| 單-6-O-(對(duì)甲苯磺酰)-α-環(huán)糊精 | Mono-6-O-(p-toluenesulfonyl)-alpha-cyclodextrin | 32860-56-3 |
| 單-6-O-(對(duì)甲苯磺酰)-γ-環(huán)糊精 | Mono-6-O-(p-toluenesulfonyl)-gamma-cyclodextrin | 97227-33-3 |
| 單-2-O-(對(duì)甲苯磺酰)-β-環(huán)糊精 水合物 | Mono-2-O-(p-toluenesulfonyl)-beta-cyclodextrin Hydrate | 84216-71-7 |
| 單-2-O-(對(duì)甲苯磺酰)-α-環(huán)糊精 | Mono-2-O-(p-toluenesulfonyl)-alpha-cyclodextrin | 93184-10-2 |
| 單-2-O-(對(duì)甲苯磺酰)-γ-環(huán)糊精 | Mono-2-O-(p-toluenesulfonyl)-gamma-cyclodextrin | 97227-32-2 |
| α-水合環(huán)糊精 | ^a-Cyclodextrin hydrate | 51211-51-9 |
| 硬脂酸-聚乙二醇-葉酸, 平均分子量 5000 | SA-PEG-FA, average M.W. 5000 | |
| (6,6)碳納米帶雙(四氫呋喃)加合物 | (6,6)Carbon Nanobelt Bis(tetrahydrofuran) Adduct |
小編：wyf 11.19
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