文獻(xiàn)：Self-targeted salinomycin-loaded DSPE-PEG-methotrexate Nanomicelles for Targeting Both Head and Neck Squamous Cell Carcinoma Cancer Cells and Cancer Stem Cells

文獻(xiàn)鏈接：https://www.tandfonline.com/doi/abs/10.2217/nnm-2016-0382

作者：Minhui Zhu,Shicai Chen,Libo Hua,Caiyun Zhang,Mengjie Chen,Donghui Chen,Yinmei Dong,Yingying Zhang,Meng Li,Xianmin Song,Huaiwen Chen &Hongliang Zheng 

摘要：

To target both head and neck squamous cell carcinoma (HNSCC) cells and cancer stem cells (CSCs) by salinomycin-loaded DSPE-PEG-MTX (synthesized using DSPE-PEG2000-NH2 and methotrexate) nanomicelles (M-SAL-MTX). Materials & methods: The characterization, antitumor activity and mechanism of M-SAL-MTX were evaluated. Results & conclusion: M-SAL-MTX showed enhanced inhibitory effect toward both HNSCC CSCs and non-CSCs compared with a single treatment of methotrexate and salinomycin. In nude mice-bearing HNSCC xenografts, M-SAL-MTX suppressed tumor growth more effectively than other controls including combination of methotrexate and salinomycin. Therefore, M-SAL-MTX may provide a strategy for treating HNSCC by targeting both HNSCC CSCs and HNSCC cells.

通過(guò)鹽霉素負(fù)載的DSPE-PEG-MTX（使用DSPE-PEG 2000-NH2和甲氨蝶呤合成）納米膠束（M-SAL-MTX）靶向頭頸部鱗狀細(xì)胞癌（HNSCC）細(xì)胞和癌癥干細(xì)胞（CSCs）。

材料與方法：對(duì)M-SAL-MTX的特性、*腫瘤活性及其作用機(jī)制進(jìn)行了評(píng)估。

結(jié)果與結(jié)論：與甲氨蝶呤和鹽霉素單一治療相比，M-SAL-MTX對(duì)HNSCC CSCs和非CSCs的抑制作用增強(qiáng)。在攜帶HNSCC異種移植物的裸鼠中，M-SAL-MTX比其他對(duì)照組（包括甲氨蝶呤和鹽霉素的組合）更有效地抑制腫瘤生長(zhǎng)。因此，M-SAL-MTX可以通過(guò)靶向HNSCC CSC和HNSCC細(xì)胞來(lái)提供治療HNSCC的策略。

相關(guān)推薦：

DSPE-PEG-PLA

DSPE-PEG-PLGA

DSPE-PEG-Progestrone

DSPE-PEG-RGD

DSPE-PEG-SC

DSPE-PEG-SCM

DSPE-PEG-SG

DSPE-PEG-SH

DSPE-PEG-Silane

DSPE-PEG-SP2-AA

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